Simon Gamache was drafted 290th overall in 2000 by the Atlanta Thrashers. He was named CHL player of the year in 2001. After spending 3 seasons with the Val d'Or Foreurs of the QMJHL, Gamache moved up to pro during the 2001-2002 season with the Chicago Wolbes. He made his NHL debut with the Thrashers during the 2002-2003 NHL season where he played 2 games and notched 2 penalty minutes.
During the 2003-2004 season, the Thrashers traded Gamache along with Kirill Safranov to the Nashville Predators for Tomas Kloucek and Ben Simon.With the Predators, he played 18 games over 3 seasons. He scored his first career NHL goal during the 2003-2004 season, that was his only point with the Predators.
The Predators placed Gamache on waivers in November of 2005 where he was claimed by the St. Louis Blues. He played 15 career games with St. Louis registering 3 Goals and 4 Assists. Then, a couple months later in January of 2006, the Blues placed Gamache on waivers where he was re-claimed by the Predators.
In 2007, the Toronto Maple Leafs signed Gamache as a free agent. With the Leafs, Gamache had 2 Goals and 2 Assists in 11 games. In November 2007, the Leafs placed Gamache on waivers for the purpose of assigning him to the Marlies. After clearing waivers, he referred to it as a "sad day" as he thought he had established himself as an NHL regular. In January 2008, the Leafs released Gamache from his contract so that he could play in Europe.
Gamache went on to play with Bern in the Swiss-A league, where he won the Swiss championship in his first season there. He currently plays for the Mannheim Eagles of the DEL in Germany.
